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1

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Herath, Ananda, Cosford, Nicholas D P

Journal:

Beilstein Journal of Organic Chemistry

Year:

2017

Language:

english

File:

PDF, 475 KB

english, 2017

2

Public health professionals' perceptions toward provision of health protection in England: a survey of expectations of Primary Care Trusts and Health Protection Units in the delivery of health protection

Paul A Cosford, Mary O'Mahony, Emma Angell, Graham Bickler, Shirley Crawshaw, Janet Glencross, Stephen S Horsley, Brian McCloskey, Richard Puleston, Nichola Seare, Martin D Tobin

Journal:

BMC Public Health

Year:

2006

Language:

english

File:

PDF, 286 KB

english, 2006

3

One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert- Butyl Esters

Herath, Ananda, Cosford, Nicholas D. P.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

4

AMYLOID PRECURSOR PROTEIN C-TERMINAL CLEAVAGE RESULTING IN THE TOXIC C31 PEPTIDE: STIMULATION OF CLEAVAGE WITH CEREVASTATIN AND INHIBITION AND CELL VIABILITY RESCUE USING SMALL MOLECULES

Poksay, Karen S., Sheffler, Douglas J., Campagna, Jesus, Spilman, Patricia, Mullenix, Michael, Bredesen, Dale E., Cosford, Nicholas D.P., John, Varghese

Journal:

Alzheimer's & Dementia

Year:

2016

Language:

english

File:

PDF, 73 KB

english, 2016

5

Autophagy in Cancer: Regulation by Small Molecules

Limpert, Allison S., Lambert, Lester J., Bakas, Nicole A., Bata, Nicole, Brun, Sonja N., Shaw, Reuben J., Cosford, Nicholas D.P.

Journal:

Trends in Pharmacological Sciences

Year:

2018

Language:

english

File:

PDF, 3.10 MB

english, 2018

6

One-Step Synthesis of 3-Aryl- and 3,4-Diaryl-(1H)-pyrroles Using Tosylmethyl Isocyanide (TOSMIC).

Nicholas D. Smith, Dehua Huang, Nicholas D. P. Cosford

Journal:

Year:

2003

File:

PDF, 129 KB

2003

7

Pyrimidine Methyl Anilines: Selective Potentiators for the Metabotropic Glutamate 2 Receptor

Essa Hu, Peter C. Chua, Lida Tehrani, Johnny Y. Nagasawa, Anthony B. Pinkerton, Blake A. Rowe, Jean-Michel Vernier, John H. Hutchinson, Nicholas D. P. Cosford

Journal:

Year:

2005

File:

PDF, 98 KB

2005

8

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: A Highly Potent, Orally Active, Metabotropic Glutamate Subtype 5 (mGlu5) Receptor Antagonist.

Dehua Huang, Steve F. Poon, Deborah F. Chapman, Janice Chung, Merryl Cramer, Thomas S. Reger, Jeffrey R. Roppe, Lida Tehrani, Nicholas D. P. Cosford, Nicholas D. Smith

Journal:

Year:

2005

File:

PDF, 13 KB

2005

9

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl] -4-methylpyridine: A Highly Potent and Orally Bioavailable Metabotropic Glutamate Subtype 5 (mGlu5) Receptor Antagonist.

Steve F. Poon, Brian W. Eastman, Deborah F. Chapman, Janice Chung, Merryl Cramer, Gregory Holtz, Nicholas D. P. Cosford, Nicholas D. Smith

Journal:

Year:

2005

File:

PDF, 9 KB

2005

10

ChemInform Abstract: Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles.

Ananda Herath, Russell Dahl, Nicholas D. P. Cosford

Journal:

Year:

2010

File:

PDF, 38 KB

2010

11

ChemInform Abstract: One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in situ Hydrolysis of tert-Butyl Esters.

Ananda Herath, Nicholas D. P. Cosford

Journal:

Year:

2011

File:

PDF, 38 KB

2011

12

Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

Shyama Sidique, Sergey A. Shiryaev, Boris I. Ratnikov, Ananda Herath, Ying Su, Alex Y. Strongin, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.47 MB

english, 2009

13

Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

Essa Hu, Peter C. Chua, Lida Tehrani, Johnny Y. Nagasawa, Anthony B. Pinkerton, Blake A. Rowe, Jean-Michel Vernier, John H. Hutchinson, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

14

2-{2-[3-(Pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl}pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Dehua Huang, Steve F. Poon, Deborah F. Chapman, Janice Chung, Merryl Cramer, Thomas S. Reger, Jeffrey R. Roppe, Lida Tehrani, Nicholas D.P. Cosford, Nicholas D. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

15

3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist

Steve F. Poon, Brian W. Eastman, Deborah F. Chapman, Janice Chung, Merryl Cramer, Gregory Holtz, Nicholas D.P. Cosford, Nicholas D. Smith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

16

Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity

Nicholas D. Smith, Steve F. Poon, Dehua Huang, Mitchell Green, Christopher King, Lida Tehrani, Jeffrey R. Roppe, Janice Chung, Deborah P. Chapman, Merryl Cramer, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 265 KB

english, 2004

17

Expedited SAR study of an mGluR5 antagonists: generation of a focused library using a solution-phase Suzuki coupling methodology

Brian Eastman, Chixu Chen, Nicholas D. Smith, Steven Poon, Janice Chung, Grace Reyes-Manalo, Nicholas D.P. Cosford, Benito Munoz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 262 KB

english, 2004

18

3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists

Lida R. Tehrani, Nicholas D. Smith, Dehua Huang, Steve F. Poon, Jeffrey R. Roppe, Thomas Jon Seiders, Deborah F. Chapman, Janice Chung, Merryl Cramer, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 150 KB

english, 2005

19

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)

Shyama Sidique, Robert Ardecky, Ying Su, Sonoko Narisawa, Brock Brown, José Luis Millán, Eduard Sergienko, Nicholas D.P. Cosford

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 262 KB

english, 2009

20

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Yiwei Li, Jun Liang, Tony Siu, Essa Hu, Michael A. Rossi, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Ronald G. Robinson, Karen Leander, Hans E. Huber, Sachin Mittal, Nicholas Cosford,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 166 KB

english, 2009

21

Identification of metabotropic glutamate receptor antagonists using an automated high-throughput screening system

Peter Hodder, Jason Cassaday, Richard Peltier, Kurtis Berry, James Inglese, Bradley Feuston, Chris Culberson, Leo Bleicher, Nicholas D.P Cosford, Chris Bayly, Carla Suto, Mark Varney, Berta Strulovici

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 616 KB

english, 2003

22

A new route to 3-heteroarylindoles

Malcolm M Campbell, Nicholas Cosford, Li Zongli, Malcolm Sainsbury

Journal:

Year:

1987

Language:

english

File:

PDF, 368 KB

english, 1987

23

[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

Nicholas D.P Cosford, Jeffrey Roppe, Lida Tehrani, Edwin J Schweiger, T.Jon Seiders, Ashok Chaudary, Sara Rao, Mark A Varney

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

24

Conformationally restricted analogues of nicotine and anabasine

Jean-Michel Vernier, Heather Holsenback, Nicholas D.P. Cosford, Jeffrey P. Whitten, Frédérique Menzaghi, Richard Reid, Tadimeti S. Rao, Aida I. Sacaan, G.Kenneth Lloyd, Carla M. Suto, Laura E. Chavez-

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 321 KB

english, 1998

25

Synthesis, characterization, and first successful monkey imaging studies of metabotropic glutamate receptor subtype 5 (mGluR5) PET radiotracers

Terence G. Hamill, Stephen Krause, Christine Ryan, Celine Bonnefous, Steve Govek, T. Jon Seiders, Nicholas D.P. Cosford, Jeffrey Roppe, Ted Kamenecka, Shil Patel, Raymond E. Gibson, Sandra Sanabria, K

Journal:

Year:

2005

Language:

english

File:

PDF, 439 KB

english, 2005

26

A Disalicylic Acid-Furanyl Derivative Inhibits Ephrin Binding to a Subset of Eph Receptors

Roberta Noberini, Surya K. De, Ziming Zhang, Bainan Wu, Dhanya Raveendra-Panickar, Vida Chen, Jesus Vazquez, Haina Qin, Jianxing Song, Nicholas D. P. Cosford, Maurizio Pellecchia, Elena B. Pasquale

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 748 KB

english, 2011

27

Recent Progress in the Synthesis and Characterization of Group II Metabotropic Glutamate Receptor Allosteric Modulators

Sheffler, Douglas J., Pinkerton, Anthony B., Dahl, Russell, Markou, Athina, Cosford, Nicholas D. P.

Journal:

ACS Chemical Neuroscience

Year:

2011

Language:

english

File:

PDF, 1.29 MB

english, 2011

28

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

Cosford, Nicholas D. P., Tehrani, Lida, Roppe, Jeffrey, Schweiger, Edwin, Smith, Nicholas D., Anderson, Jeffrey, Bristow, Linda, Brodkin, Jesse, Jiang, Xiaohui, McDonald, Ian

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 54 KB

english, 2003

29

Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM

Douglas J. Sheffler, Cody J. Wenthur, Joshua A. Bruner, Sheridan J.S. Carrington, Paige N. Vinson, Kiran K. Gogi, Anna L. Blobaum, Ryan D. Morrison, Mitchell Vamos, Nicholas D.P. Cosford, Shaun R. Sta

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 1.58 MB

english, 2012

30

Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist

Tadimeti S. Rao, Pamala B. Adams, Lucia D. Correa, Emily M. Santori, Aida I. Sacaan, Richard T. Reid, Nicholas D.P. Cosford

Journal:

Year:

2008

Language:

english

File:

PDF, 1.01 MB

english, 2008

31

In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine)

Jeffery J. Anderson, Margaret J. Bradbury, Darlene R. Giracello, Deborah F. Chapman, Greg Holtz, Jeffrey Roppe, Chris King, Nicholas D.P. Cosford, Mark A. Varney

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

32

Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist

Nicholas D.P Cosford, Leo Bleicher, Jean-Michel Vernier, Laura Chavez-Noriega, Tadimeti S Rao, Robert S Siegel, Carla Suto, Mark Washburn, G.Kenneth Lloyd, Ian A McDonald

Journal:

Pharmaceutica Acta Helvetiae

Year:

2000

Language:

english

File:

PDF, 135 KB

english, 2000

33

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABAA signaling

Aleksandra Klodzinska, Ewa Tatarczyńska, Ewa Chojnacka-Wójcik, Gabriel Nowak, Nicholas D.P Cosford, Andrzej Pilc

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 294 KB

english, 2004

34

Corrigendum to “Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor antagonist does not involve GABAA signaling” [Neuropharmacology 47 (2004) 342–350]

Aleksandra Klodzinska, Ewa Tatarczyńska, Ewa Chojnacka-Wójcik, Gabriel Nowak, Nicholas D.P. Cosford, Andrzej Pilc

Journal:

Neuropharmacology

Year:

2004

Language:

english

File:

PDF, 44 KB

english, 2004

35

ChemInform Abstract: Automated Multistep Continuous Flow Synthesis of 2-(1H-Indol-3-yl)thiazole Derivatives.

Pagano, Nicholas, Heil, Marintha L., Cosford, Nicholas D. P.

Journal:

Year:

2012

File:

PDF, 36 KB

2012

36

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

Kiffer-Moreira, Tina, Yadav, Manisha C, Zhu, Dongxing, Narisawa, Sonoko, Sheen, Campbell, Stec, Boguslaw, Cosford, Nicholas D, Dahl, Russell, Farquharson, Colin, Hoylaerts, Marc F, MacRae, Vicky E, Mi

Journal:

Journal of Bone and Mineral Research

Year:

2013

Language:

english

File:

PDF, 1.15 MB

english, 2013

37

One-Step Synthesis of 3-Aryl- and 3,4-Diaryl-(1 H )-Pyrroles Using Tosylmethyl Isocyanide (TOSMIC)

Smith, Nicholas D., Huang, Dehua, Cosford, Nicholas D. P.

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 56 KB

english, 2002

38

A Practical and Efficient Synthesis of the Selective Neuronal Acetylcholine-Gated Ion Channel Agonist ( S )-(−)-5-Ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine Maleate (SIB-1508Y)

Bleicher, Leo S., Cosford, Nicholas D. P., Herbaut, Audrey, McCallum, J. Stuart, McDonald, Ian A.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 120 KB

english, 1998

39

The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Function in Rats

Jin, Xinchun, Semenova, Svetlana, Yang, Li, Ardecky, Robert, Sheffler, Douglas J, Dahl, Russell, Conn, P Jeffrey, Cosford, Nicholas DP, Markou, Athina

Journal:

Neuropsychopharmacology

Year:

2010

Language:

english

File:

PDF, 784 KB

english, 2010

40

Fully Automated Continuous Flow Synthesis of Highly Functionalized Imidazo[1,2-a] Heterocycles

Herath, Ananda, Dahl, Russell, Cosford, Nicholas D. P.

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 390 KB

english, 2010

41

Rapid Multistep Synthesis of 1,2,4-Oxadiazoles in a Single Continuous Microreactor Sequence

Grant, Daniel, Dahl, Russell, Cosford, Nicholas D. P.

Journal:

Journal of Organic Chemistry

Year:

2008

Language:

english

File:

PDF, 154 KB

english, 2008

42

( S )-(−)-5-Ethynyl-3-(1-methyl-2-pyrroli- dinyl)pyridine Maleate (SIB-1508Y): A Novel Anti-Parkinsonian Agent with Selectivity for Neuronal Nicotinic Acetylcholine Receptors

Cosford, Nicholas D. P., Bleicher, Leo, Herbaut, Audrey, McCallum, J. Stuart, Vernier, Jean-Michel, Dawson, Heather, Whitten, Jeffrey P., Adams, Pamala, Chavez-Noriega, Laura, Correa, Lucia D., Crona,

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 145 KB

english, 1996

43

Encyclopedia of Reagents for Organic Synthesis || Iodine-Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 46 KB

english, 2001

44

2-Aminopyridines via Reaction of Pyridine N -Oxides and Activated Isocyanides

Vamos, Mitchell, Cosford, Nicholas D. P.

Journal:

Journal of Organic Chemistry

Year:

2014

Language:

english

File:

PDF, 594 KB

english, 2014

45

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Bromide

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

46

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 390 KB

english, 2001

47

Encyclopedia of Reagents for Organic Synthesis || Copper(II) Chloride

Cosford, Nicholas D. P.

Year:

2001

Language:

english

File:

PDF, 184 KB

english, 2001

48

An Improved Method for the Synthesis of Cationic (.eta.5-Cyclopentadienyl)(.eta.3-allyl)Mo(CO)(NO) Complexes: The Benefit of 1,2-Dimethoxyethane as a Solvent

Cosford, Nicholas D. P., Liebeskind, Lanny S.

Journal:

Organometallics

Year:

1994

Language:

english

File:

PDF, 722 KB

english, 1994

49

A Novel Method for the Racemization of 5-Bromonicotine

Bleicher, Leo S., Cosford, Nicholas D. P.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 42 KB

english, 1999

50

4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]- phenol Hydrochloride (SIB-1553A): A Novel Cognitive Enhancer with Selectivity for Neuronal Nicotinic Acetylcholine Receptors

Vernier, Jean-Michel, El-Abdellaoui, Hassan, Holsenback, Heather, Cosford, Nicholas D. P., Bleicher, Leo, Barker, Geoffrey, Bontempi, Bruno, Chavez-Noriega, Laura, Menzaghi, Frederique, Rao, Tadimeti

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 53 KB

english, 1999